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  • A new drug approved for weight-loss with the U.S. Food and Drug Administration had great results in many studies, but it isn't a panacea for losing weight. It must be found in combination with a low-calorie diet and frequent exercise in order to be effective.

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    Researchers found that participants taking this drug for any year, lost excess weight within a month and have kept the weight off during the entire 56 weeks with the study. Contrave is really a combination of the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which can make them more potent and safer.

    Combo-pilling is the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that as of right now there aren't long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures are a side effect with Contrave and must not be taken in people who have seizure disorders. The drug can also raise hypertension and heart rate, and shouldn't be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure levels and heartbeat and must not used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients having a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert medical professionals and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver soon after uptake from your intestines and possesses no therapeutic effect. Buprenorphine may be the active substance; it can be absorbed within the tongue (and during the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who have had gastric bypass, in which the first section of the intestine is bypassed and the stomach contents empty into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy the location where the drug is taken up from the duodenum and transferred directly to the liver from the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken on by servings of the intestine which are not served from the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.